Los Penitentes sits in Mendoza, Argentina, at 2580–3360 m. Getting there mostly comes down to altitude and whether you're driving or flying in — here's the practical part.
With 2580–3360 m of elevation, the access road often requires winter or M+S-rated tyres, and snow chains can be mandatory on heavy snow days. Check road conditions before you drive up and build in extra time for the last few kilometres of mountain road.
The reference airport is Gobernador Francisco Gabrielli (MDZ), in Mendoza — from there, it's 2h 30min by car.
Most resorts have paid parking right by the lifts and free options a bit further out with a shuttle. Arriving early on busy days (weekends, holiday weeks) is the difference between parking right at the slopes or walking quite a bit further.